In the 35th minute of the match between Brentford and Manchester United, with the score standing at 2-1 in favor of the home side, Manchester United`s coaching staff had to make the first substitution of the game. Matthijs De Ligt, the Dutch defender who previously played for Juventus from 2019 to 2022, was withdrawn due to an injury. He was replaced by Harry Maguire. This substitution occurred just days after De Ligt had returned to training with the full squad.